NeuroTrio is a physician recommended protocol for patients who are concerned about restoring and maintaining good cognitive health
NeuroTrio is a three-part specialty nutraceutical protocol developed to support adults experiencing brain fog symptoms, including challenges with focus, concentration, recall, mental clarity, and energy. In an 8-week human clinical study, the NeuroTrio Protocol was evaluated in 40 adult participants experiencing brain fog associated with trauma, illness, chemotherapy exposure, or similar factors. Participants were assessed using both self-reported cognitive wellness measures and the Montreal Cognitive Assessment, commonly known as MOCA.
Brain fog is commonly used to describe a collection of cognitive symptoms where the individual notices some loss of brain function. This is typified by reduced clarity, mental sluggishness, loss of recall and diminished mental energy.
Brain fog can occur for several reasons: aging, poor sleep habits, underlying disease or illness, poor nutrition, gut irritation or digestive issues, depression, and prescription drugs.
A Three-Part Protocol for Cognitive Support
The brain depends on a careful balance of nutrients, cellular energy, neurotransmitter activity, and overall neurological health. Numerous factors—including illness, trauma, aging, chemotherapy exposure, medication effects, stress, and nutritional imbalance—may disrupt that balance and contribute to cognitive symptoms.
NeuroTrio was developed as a coordinated three-part protocol designed to support cognitive wellness from multiple angles:
Rather than focusing on a single ingredient, NeuroTrio combines these three components into one integrated daily protocol.
The NeuroTrio Protocol was evaluated in an 8-week, open-label, one-arm pilot study designed to assess cognitive function, self-reported brain fog symptoms, and overall well-being in adults experiencing brain fog.
The study included 40 participants from across the United States, ages 18 to 80. Participants received a NeuroTrio dietary supplement kit containing the proprietary NeuroTrio formulation, a broad-spectrum probiotic, and an omega-3 supplement. The protocol was taken twice daily, once in the morning and once in the afternoon.
Proprietary blend, probiotic, and omega-3 support working together
40 adults, ages 18–80
NeuroTrio Cognitive Blend + probiotic + omega-3
MOCA and self-reported cognitive wellness questionnaire
Baseline and biweekly assessments over 8 weeks
No adverse effects reported during the study
Measuring Cognitive Function and Brain Fog Symptoms
The study evaluated both objective and subjective measures of cognitive wellness.
The primary outcome was change in MOCA scores. MOCA evaluates several areas of cognitive function, including attention, memory, language, visuospatial skills, and executive function.
Participants also completed a self-reported questionnaire using a 5-point scale to assess overall brain health, ability to concentrate, ability to recall instructions, stress and anxiety level, ability to focus, and energy level.
Attention
Memory
Language
Executive function
Visuospatial skills
Overall brain health
Concentration
Recall
Stress / anxiety
Focus
Energy
Statistically Significant Improvements
by Week 8
The study reported statistically significant improvements across multiple cognitive and well-being measures by Week 8, with the most substantial benefits observed between baseline and the end of the study period.
Participants reported significant improvement in overall brain health from baseline to Week 8. The report identified a significant time effect on brain health ratings, with the most pronounced improvement achieved by the end of the 8-week period.
Self-reported concentration improved significantly during the study. The largest improvement was observed between baseline and Week 8, supporting NeuroTrio’s potential role in cognitive support for individuals experiencing brain fog symptoms.
Participants reported significant improvement in their ability to recall instructions. Improvements were observed over the study period, with notable gains from Week 4 onward and the strongest results by Week 8.
Self-reported focus improved significantly over time, with significant improvement evident by Week 8.
Energy levels improved significantly from baseline to Week 8. The study findings suggest that the NeuroTrio Protocol may contribute to improved perceived mental energy over time.
MOCA scores improved significantly over time, with the report noting progressive cognitive improvement across the study period.
The clinical report found that the strongest improvements were observed by Week 8, suggesting a cumulative effect with continued use of the full NeuroTrio Protocol. Improvements were seen across overall brain health, concentration, recall, focus, energy, and total mean cognitive wellness score.
Initial cognitive and brain fog assessments
Early follow-up
Emerging improvements in some measures
Continued progress
Most pronounced improvements across key outcomes
Safety and tolerability were important parts of the NeuroTrio study. According to the clinical report, no study participants reported adverse effects related to the NeuroTrio Protocol during the 8-week study period.
As with any dietary supplement, individuals who are pregnant, breastfeeding, taking prescription medications, managing a medical condition, or under physician care should consult a healthcare professional before beginning NeuroTrio.
The NeuroTrio study was designed to evaluate the Protocol as a nutritional supplement approach to supporting cognitive function and well-being. The study did not seek to claim treatment, cure, or mitigation of a specific disease or disorder.
The findings support NeuroTrio’s potential as a non-pharmaceutical option for adults seeking support for cognitive wellness, mental clarity, focus, recall, and energy.
From professionals and caregivers to adults navigating everyday brain fog, NeuroTrio is designed to support the moments that matter most: better focus, clearer thinking, steadier energy, and more confidence in daily life.
NeuroTrio supplements were a life saver for me after an allergic reaction to anesthesia and painkillers from surgery. I was disoriented and brain fogged. Taking them was like having the lights go back on!
Consulting with Dennis has been beneficial and the brain fog regimen is helping my memory. Doing online games, such as Luminosity adds to memory improvement.
Since a couple days before Thanksgiving, the verbal mixups I'd been experiencing dwindled to zero and I’ve had few instances since. A big improvement!
Ready to Learn How
NeuroTrio Works?
NeuroTrio combines targeted brain-supportive nutrients, probiotic support, and omega-3 support into one simple daily protocol.
NeuroTrio combines targeted brain-supportive nutrients, probiotic support, and omega-3 support into one simple daily protocol.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.